Longevity starts in the mouth.
ORIGIN is an oral longevity platform. An at-home saliva test and three-minute sleep and jaw screens find what is driving inflammation. Licensed telehealth physicians prescribe treatment to the door, a re-test proves it worked, and dentists trained and certified by the ORIGIN Academy deliver the TMJ, airway and peptide care that follows.
Longevity medicine measures everything. Except the mouth.
Chronic, low-grade inflammation is a core driver of age-related disease. Gum disease is a chronic infection on a wound the size of a palm, open to the bloodstream every day. Oral health tracks lifespan, yet longevity clinics run 100+ blood biomarkers and leave the mouth to a twice-a-year cleaning.
Franceschi et al., Nat Rev Endocrinol 2018; Peng et al., Biosci Rep 2019; Romandini et al., J Dent Res 2021. Associations, not proof of causation.
Oral longevity care in four pillars.
One sign-up covers the infection, the repair, the jaw and the airway. Care starts at home and moves to the dental chair only when it needs to.
Find and clear it
An at-home saliva test for 8 pathogens; a prescription rinse to the door; a re-test proves it worked.
Rebuild and protect
Peptide protocols matched to each patient’s inflammation pattern by the ORIGIN Rank Engine.
TMJ care, home first
An online screener, a provisional plan with medication and exercises, then an ORIGIN dentist with TMJ training.
Sleep and breathing
STOP-BANG and Epworth at sign-up; a physician-ordered home sleep test; oral appliance therapy.
Every ORIGIN profile maps to five body systems.
Each system is rated Low, Moderate or High from the saliva result and the at-home screens, with blood markers added only when the re-test calls for them. Patients and physicians see the same map.
Neurologic balance
Stress-axis load and neural health, measured at home: a daily salivary cortisol curve, plus self-reported clenching and jaw pain.
Airway & respiratory
Sleep-disordered breathing, screened remotely, with a home sleep apnea test when the screen is positive.
Cardiovascular
Periodontal pathogens and vascular inflammation markers.
Immune & inflammatory
Microbiome dysbiosis and cytokine burden.
Digestive & metabolic
Oral seeding of the gut, blood sugar and insulin.
Dentists were never trained for oral longevity. ORIGIN trains them.
ORIGIN is, at its core, an education company with treatment protocols built in. The Academy teaches dentists what dental school did not: how to screen for oral longevity, how peptides support oral healing, and how to treat the jaw. Every module ships with the regimen cards, questionnaires, consents and software to use it the next day.
Average TMD confidence of students and faculty at a US school that teaches TMD across its curriculum. Lowest score: adjusting occlusal appliances.
Peptide therapy is not part of standard dental training. Dentists hear about it from patients and wellness clinics, not from a protocol.
No accepted protocol ties saliva pathogens, sleep scores, jaw health and blood markers into one exam and one plan.
Why peptides, why now
The eight ORIGIN peptides, the science and the 2026 regulatory picture.
Oral longevity screening
Reading the saliva report, STOP-BANG and Epworth, the jaw screener, and when blood is warranted.
TMJ mastery
DC/TMD exam, home-first protocols, splint fabrication and adjustment, referral boundaries. Hands-on.
Clear and verify
Organism-matched rinse regimens, the nitrate-sparing guardrail and the 8-week re-test.
Airway and sleep
Screening, physician co-management and oral appliance therapy.
Peptide protocols
Rank Engine sequencing, conflict rules, consent, compounding and compliance.
Practice integration
Cash-pay pricing, team workflow, telehealth co-management and anti-kickback rules.
Format
Online modules, then a live hands-on weekend at Core Smiles in New York. Taught by a prosthodontist and TMJ specialist who directed NYU’s Advanced Esthetics and Occlusion Program.
From screener to splint: the protocol most dentists never got.
ORIGIN Certified
Screening, clear-and-verify and peptide protocols. Listed in the ORIGIN directory.
TMJ Certified
Adds the hands-on TMJ module. Receives ORIGIN jaw-screen referrals.
Airway Certified
Adds airway and sleep. Receives sleep-screen referrals for oral appliance therapy.
Every certified practice gets the protocol library, the Rank Engine and Report Generator, patient materials and the ORIGIN maintenance line.
Join the founding cohortFricton V et al., Cranio 2026;44(2):249–262 (145 students and faculty at one US dental school). Spear Education, State of Dental CE 2022. Accredited CE credit (ADA CERP or AGD PACE) is being pursued and is not yet approved. Peptides referenced are not FDA-approved for these uses.
One sign-up. One clear sequence. Starts at home.
ORIGIN was built and refined in clinical practice at Core Smiles in New York. Nationally, the same logic runs on an at-home kit, licensed telehealth physicians and a certified dentist network. Many patients will not walk into a dental office first; ORIGIN does not ask them to.
Screen
The ORIGIN kit arrives at home: a saliva test plus three-minute sleep and jaw questionnaires, with a prepaid return.
Clear
A prescription antimicrobial rinse, matched to the organisms found, delivered to the door within days of results.
Clean
A certified ORIGIN dentist removes the calculus that rinses cannot, when the patient is ready.
Verify
A second saliva kit at 8 weeks. Bloodwork is ordered only if pathogens persist.
Repair
A peptide protocol matched by the Rank Engine, started only after the infection is cleared and verified.
Maintain
Lozenges, toothpaste, rinse and floss by subscription; a re-test every 6 months.
Jaw screen positive?
Telehealth review, a provisional TMJ plan and home exercises, then an ORIGIN TMJ dentist.
Sleep screen positive?
A partner physician orders a home sleep apnea test; diagnosed patients choose CPAP or an oral appliance.
Bacteria still high?
The ORIGIN blood panel checks whether inflammation has reached the body. Never the first step.
Prescriptions are written by physicians in a partner telehealth medical group and shipped by licensed pharmacies under the ORIGIN brand. Rinses reduce bacterial load but do not remove calculus; the re-test decides whether a cleaning is required.
Every organism points to a testable blood signal.
When pathogens persist after treatment, the ORIGIN Systemic Verification Panel checks whether inflammation has reached the body. It maps eight salivary organisms to eleven blood markers, and every report discloses the evidence tier, including the organisms whose evidence is still emerging.
View as table
| Organism | hs-CRP | Lipid panel | ApoB | CBC | HbA1c | Fasting insulin | Fasting glucose |
|---|
These are associations, not proof of causation, and every ORIGIN report says so.
Six steps. Nothing advances without passing its gate.
Every patient moves through the same six steps, and each one has an objective condition that must be met before the next begins. The steps spell the name: Observe, Rank, Intervene, Gate, Integrate, Normalize.
Matched and sequenced by the engine, never chosen from a menu.
Peptide stages are prescribed by licensed clinicians after the re-test, compounded by licensed 503A pharmacies, and launch only as each compound's regulatory status allows. BPC-157, KPV and ten others left FDA’s Category 2 list in April 2026, and an FDA advisory committee backed BPC-157, KPV, TB-500 and MOTS-c for compounding in July 2026; final rulemaking is pending. No peptide named here is FDA-approved for these uses.
TMJ care that starts at home.
About one in three people show signs of temporomandibular disorder, and few venture-scale companies treat it. ORIGIN screens for it at sign-up.
- ScreenThe ORIGIN Jaw & TMJ Questionnaire, built on the validated TMD Pain Screener (99% sensitivity, 97% specificity), plus a pain map, function and red-flag checks.
- ReviewA telehealth clinician reviews the answers and makes a provisional diagnosis and plan.
- RelieveA short, safety-screened course of anti-inflammatory and muscle-relaxant medication, with guided home jaw exercises.
- ReferAn ORIGIN dentist with TMJ training for the exam, a custom splint and follow-up.
Gonzalez et al., JADA 2011; Schiffman et al., DC/TMD 2014. A definitive TMD diagnosis requires an in-person exam. Red flags stop the online pathway and send the patient to urgent care.
Sleep apnea: the longevity risk hiding at night.
Every pause in breathing starves the body of oxygen and drives inflammation, night after night. Most people who have it do not know.
Benjafield et al., Lancet Respir Med 2019. A physician orders and interprets every sleep test.
Pathway first, then the peptide.
The dentist enters findings from the first exam and health history; no bloodwork is needed. The engine ranks which inflammatory pathway is driving this patient, matches what to use and flags what to avoid, and checks every plan for conflicts. It is the software certified dentists license. Live demonstration available to partners under NDA.
Request a demonstration Partner access →Already built. Already producing reports.
The Report Generator starts with the saliva result alone. It produces a plain-language patient report with every acronym defined, a physician summary, a prescription plan, a dentist referral and the patient email. At the 8-week re-test it recommends bloodwork only if pathogens persist. Every output shows the evidence behind it and says "associated with," never "diagnostic."
An at-home kit that is a system, not a tube.
Saliva test, sleep and jaw screens and a prepaid return in one ORIGIN-branded box.
Response re-test
A second saliva kit at 8 weeks proves the pathogens have cleared. Blood is drawn only if they have not.
Household kit
Periodontal pathogens can be transmitted between partners, so treat the household.
Nitric-oxide guardrail
Agents are chosen to spare the oral bacteria that help regulate blood pressure.
Dentist handoff
High-burden results go to an in-network ORIGIN dentist. Antimicrobial rinses alone will not remove dental calculus, the source of periodontal pathogens.
Daily care that keeps the result, by subscription.
Once the infection is cleared, the ORIGIN bioactive line keeps it that way. Refilled automatically, with a saliva re-test every 6 months to keep the loop closed.
Telehealth physicians prescribe. Certified dentists treat. ORIGIN supplies the clinical logic.
Prescriptions are written by physicians in an affiliated telehealth medical group and shipped by licensed pharmacies under the ORIGIN brand, so patients can start treatment the week their results arrive, without waiting for a dental appointment. Certified dentists license the ORIGIN software for a flat monthly fee and take the patients who need the chair. ORIGIN never pays or charges per referral.
- Licensed telehealth physicians review and prescribe in every state
- Licensed pharmacies ship rinses, TMJ medication and peptides
- Physician-ordered home sleep tests and, when needed, phlebotomy
- Certified ORIGIN dentists: cleanings, TMJ splints, sleep appliances, peptide follow-up
- The ORIGIN kit, sleep and jaw screens
- Report Generator, built and running
- Rank Engine for pathway-matched peptides, licensed to dentists
- The ORIGIN Sequence: six steps, each gated
- The ORIGIN Academy: certification, protocol library and the directory
- ORIGIN maintenance line
- An outcome dataset linking oral findings, treatment and longevity markers
Michael Gulizio, DMD, MS
ORIGIN started in a working practice. It reflects nearly two decades of treating the mouth as part of the whole patient.
Born in Brooklyn and educated at the University of Pennsylvania, Dr. Gulizio returned to New York to practice. He co-founded Core Smiles in 2007, a practice in NoMad, Manhattan that covers all of dentistry, from prosthodontics and implants to TMJ care and longevity medicine. For several years he directed NYU’s Advanced Esthetics and Occlusion Program, training dentists from around the world. His work sits where precision dentistry meets systemic and longevity medicine, and ORIGIN is the system he built to make that link measurable for every patient.
- Prosthodontist; DMD, MS, MSEd, MSciDent
- Founder and CEO, Core Smiles Aesthetic & Implant Dentistry, NoMad, New York (co-founded 2007)
- Founder and CEO, OralIQ LLC, owner of the ORIGIN™ platform
- Former Program Director, Advanced Esthetics and Occlusion Program, NYU, teaching dentists from around the world
- TMJ and orofacial pain specialist with clinical focus in sleep, airway and longevity medicine
- Certified in peptide therapy implementation, Seeds Scientific Research & Performance Institute
- Creator of the ORIGIN™ Precision Oral-Systemic Assessment, in clinical use at Core Smiles
- Author of the forthcoming book Oral Intelligence, on the mouth as the origin of systemic health
Request the partner brief.
The full brief covers the oral longevity model, the ORIGIN Academy, the four pillars, the evidence base, the New York pilot and a live demonstration of the Rank Engine and Report Generator. It is shared under a mutual NDA.
Core Smiles · 1182 Broadway, 4th Floor · New York, NY 10001
(212) 251-0044